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Candistat (Itraconazole)

Candistat is a fat soluble synthetic triazole antifungal drug. It has the same mechanism of action as all azoles and prevents the formation of ergosterol necessary for the cell membranes of fungi. Studies with Candistat commenced in 1984 and the drug was licensed in 1991. It is now off patent, although the IV and oral solution formulations are still patent protected. It interferes with fungal biosynthesis of ergosterol like all azoles, by interfering with the activity of 14alpha demethylase. Candistat is one of the most broad spectrum antifungals available and includes activity in Aspergillus spp, Blastomyces dermatitidis, Candida (all species and most isolates including some fluconazole resistant isolates), Coccidioides spp., Cryptococcus spp., Histoplasma spp, Paracoccidioides brasiliensis, Scedosporium apiospermum and Sporothrix schenckii. It is also active against all skin fungi. It is not active against Mucorales or Fusarium spp. and a few other rare fungi. Until the development of posaconazole, it was the most active against black moulds, including Bipolaris, Exserohilum etc. Resistance to Candistat is described in Candida spp. and in Aspergillus fumigatus and A. niger.

Other names for this medication:
Itraconazole, Sporanox, Fulcover, Icoz, Candistat,

Similar Products:
Ropark, Sildigra, Aztor, Cefixima, Ariclaim, Aldoril, Gatilox, Darinol, Pinamox, Acyrax, Isosorbide, Blumox, Zoldem, Rabeprazol, Valcivir, Flamus, Elazor, Protoloc, Tizanidine, Zithromax, Tacrolimus, Lagatrim, Prinivil, Medifen, Grifulvin, Rinolast, Salvacam, Ultop, Motifene, Clindal, Zoroxin, Zocam, Saphire,

Candistat is also sometimes used to treat other types of fungal infections and to prevent fungal infections in people who have human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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CJ-463 was found to similarly reduce tumor growth in uPA receptor knockout mice, but was ineffective in uPA knockout mice. Home informatics has the potential to become a means of providing good care at home. The World Health Organization recognises, and has done for over 10 years, that alcohol use during pregnancy which results in Foetal Alcohol Spectrum Disorder is the leading cause of environmental-related birth defects and mental retardation in the Western world. mucronata, significant positive F(IS) values were found, indicating deviation from Hardy-Weinberg proportions and a deficiency of heterozygotes.

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To establish an LC-MS method for rapid simultaneous determination of adenine,adenosine and cordycepin in Cordyceps sinensis. C-type natriuretic peptide (CNP) and nitric oxide (NO) are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. Re-excision for recurrence of the myxosarcoma in the left atrium was performed in the latter case as a second surgical procedure. Photocurable liquid biodegradable copolymers: in vitro hydrolytic degradation behaviors of photocured films of coumarin-endcapped poly(epsilon-caprolactone-co-trimethylene carbonate). The authors report on an acute bitemporal visual field depression with spontaneous reversibility of the defects, associated with necrotic pituitary adenoma.

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Interdisciplinary education in palliative care: impact on attitudes of students in medicine, nursing, pharmacy, social work, and chaplaincy. By this publication, we wish to serve notice that these provisions will be implemented, on the dates indicated, even though specific regulations have not been promulgated. All TBECH diastereomers induced PSA expression in LNCaP cells even though the AR present in these cells is mutated (T877A). Role of free phenol in the development of encephalopathy in patients with endogenous toxicoses During lactation, mammary gland indices increased to Day 5 and then decreased gradually from Day 10 to Day 20.

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Additionally, the hypofrontal pattern remained unchanged suggesting that organic brain damage can develop as a result of chronic high-dose benzodiazepine abuse. Antioxidants are a small group of substances that protect living cells from the destructive consequences of powerful oxidizing intermediates that can be formed from oxygen. The effects of continuous clonidine infusion (10 micrograms/kg/h for 10 days) and the cessation of this infusion on the circadian body temperature rhythm of the spontaneously hypertensive (SH) rat were examined. Nine adult cadaveric heads (18 sides) were examined after injection of colored silicon. Measurement properties of the Vitiligo Impact Scale-22 (VIS-22), a vitiligo-specific quality-of-life instrument.

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To evaluate the concordance between intraoperative ultrasound (IOUS) and abdominal ultrasound (US) for the characterization of focal liver lesions in patients with colorectal cancer, and to evaluate the way in which IOUS influences the initially established hepatic surgical protocol based on abdominal US only. We demonstrate the nature of PTEN as an IRS1 phosphatase by direct biochemical analysis and cellular reconstitution, showing that NEDD4 supports insulin-mediated glucose metabolism and is required for the proliferation of IGF1 receptor-dependent but not EGF receptor-dependent tumor cells. 2-3-fold higher in vitro photodynamic activity in different cell lines under identical conditions.

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Preperitoneal approach to parastomal hernia with coexistent large incisional hernia. It is found on some, but not all, T cell lines but is absent from any other hematopoietic cell lines tested. togolense (Alberet et coll., 1978) and therefore this appears to constitute a good criterium for the taxonomy of this group. Oxidative stress in methamphetamine-induced self-injurious behavior in mice. We constructed hybrid Pseudomonas strains in which the bphA1 gene (coding for a large subunit of biphenyl dioxygenase) is replaced with the todC1 gene (coding for a large subunit of toluene dioxygenase of Pseudomonas putida Fl) within chromosomal biphenyl-catabolic bph gene clusters.

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Implications for the pathophysiology of chronic myocardial hibernation. All sorption isotherms were highly nonlinear and were fitted well by Freundlich and Polanyi-Manes models. Maternal psychological problems associated with neonatal intensive care admission. Presence of estrogen receptors in the hen hypothalamus and pituitary. Activating Transcription Factor 3 (ATF-3) was heavily induced by hypoxia in A549 cells but not in HMEC-1 cells.

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Illicit substance use is a potent risk factor for poor outcomes in schizophrenia, yet methods for detecting substance use consistently underestimate the problem. The number needed to treat (NNT), calculated as the reciprocal of the absolute risk reduction, is a parameter that provides quantitative information on the efficacy of therapeutic interventions. Somatic mutations during an immune response in Xenopus tadpoles. Bacitracin or bovine serum albumin was used to inhibit such degradation in a dose-dependent fashion to allow meaningful data analysis. Effects of Greek Orthodox Christian Church fasting on serum lipids and obesity.

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Development and clinical evaluation of sdaA loop-mediated isothermal amplification assay for detection of Mycobacterium tuberculosis with an approach to prevent carryover contamination. The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxim. Severe acute respiratory syndrome is a new disease that is highly contagious and is spreading in the local community and worldwide.

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Resonant photoacoustic cell for pulsed laser analysis of gases at high temperature. Facile anchoring on TiO(2) powder is obtained and scrutinized by FT-IR spectroscopy. The gradient boosting algorithm and random boosting for genome-assisted evaluation in large data sets. The pathogenesis of uterine pathologies is discussed following new research results and new knowledge on the mechanisms of uterine defense. The aim of this cross-sectional study is to analyse the relationship between viral load, total CD4 lymphocyte count, and percentage of CD4 lymphocytes to the occurrence of OC.

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A controlled spatial distribution of functional units in the two dimensional nanospace of layered silicates and titanates. A storage protein-like Trypsin inhibitor from the Moth Bean (Phaseolus acutifolius) with antiproliferative activity toward lymphoma cells. We identified two forms of dimers: DBD-type dimers and RD-type dimers. In the present study, two new types of arm ergometers, the Cybex Upper Body Exercise ergometer (CUBE) and the Schwinn Air-Dyne ergometer (SAE), have been evaluated and compared with older methods for determining aerobic capacities of wheelchair-confined subjects.

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Our aim was to determine whether inter-individual differences in leukocyte telomere length contribute to the susceptibility of PAD. Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses. Accumulation of sulfur-containing compounds and their bacterial mediated reductions have led to the emission of pungent odors from stagnant water bodies. The sleep-time responses to ethanol, pentobarbital, and methyprylon were assessed in various generations derived from crossing the long-sleep (LS) and short-sleep (SS) mouse lines in order to assess whether common or different genes regulate response to these agents. In contrast, PolyPhen- and SIFT-derived scores only showed significant differences between CF-causing and non-CF variants.

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The time until pulmonary artery catheter replacement can be extended to 7 days if there is no evidence of catheter-related infection. Calcium antagonists: current and future applications based on new evidence. Since 1978, the ASD has consistently been implanted either at the time of primary shunt insertion (66 neonates, mean follow-up 11 years) or during revisions of preexisting shunts (54 children, mean follow-up 11.8 years). The evaluation was again performed by 5 radiologists with softcopy reading.

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Immunofluorescence analysis demonstrates differential subcellular localization of Myc-tagged CAP isoforms in 3T3-L1 adipocytes. The nineteen patients in Group I were treated with a 95 fixed-angle screw-plate (Dynamic Condylar Screw), and the twenty patients in Group II were treated with an intramedullary nail (Proximal Femoral Nail). The fatalities increased three-fold and injuries ten-fold over the same period. A coupled-mode theory is presented to describe the dynamics of the molecular director induced by an elliptically polarized light plane wave normally incident onto a homeotropic liquid crystal film.

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Whereas baclofen was anticonvulsant and CGP 35348 proconvulsant in most animals, there were distinct age-related differences in the effectiveness of these drugs and the antagonist had some anticonvulsant activity in adults. The identification and management of schizophrenia in childhood. Changes in preload and afterload did not affect the magnitude of cyclic variation in IB. The data revealed no difference in exercise duration or mitral valve area between NYHA classes, but demonstrated an excellent correlation between exercise duration and severity of mitral valve stenosis determined at cardiac catheterization (cath MVA). Our findings suggest that some of the behavioral abnormalities produced by uncompetitive NMDAR antagonists may result from aberrant activity in cortico-subcortical pathways.

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Application of serine- and threonine-derived cyclic sulfamidates for the preparation of S-linked glycosyl amino acids in solution- and solid-phase peptide synthesis. Conformational studies on the gramicidin A transmembrane channel in lipid micelles and liposomes.

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Performance indicators: INCA (cardiovascular indicators) project This paper discusses some of the factors that may affect the effectiveness of these methods. In contrast to similar substantial risk industries, there is no standard instrument capable of detecting the potential of surgical residency candidates to develop such skills. A very important practical fact is that the calculations can be performed on a normal computer.

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Once atrial fibrillation (AF) progresses to sustained forms, adverse outcomes increase and treatment success rates decrease. Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations. Plasma lathosterol as a screening test for bile acid malabsorption due to ileal resection: correlation with 75SeHCAT test and faecal bile acid excretion.

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Immunological studies indicated that the linker region, along with elements of the CBD, is a major immunogenic epitope. Characterization of binding site of uremic toxins on human serum albumin. dermatologists for well-defined facial BCC and to investigate the effect that variations in site and clinical indicators might have on those intentions.

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Subjective memory strength should increase for targets and simultaneously decrease for foils following a strongly encoded list compared with a weakly encoded list. Percutaneous microwave tissue coagulation in liver biopsy: experimental and clinical studies. These obserations imply that the rat has at least two distinct groups of Ia molecules. Meta-analysis of polytetrafluoroethylene bypass grafts to infrapopliteal arteries. As a result of the pivotal role of mTOR in signaling, the aberrant regulation of mTOR has been implicated in several disease processes, including cancer, diabetes, ocular diseases and neurodegenerative disorders, as well as in lifespan extension.

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Twenty-five postnatally depressed mothers with infants less than one year participated in a randomized, double-blind, placebo controlled within-subject clinical study in 2011. Aberrations in protein phosphorylation have been linked to human diseases including cancer. Professionalism is a core competency in surgery (as in all of medical practice), and its presence or absence affects all aspects of clinical education and practice, but the ways in which professional values and attitudes are best transmitted to developing generations of surgeons have not been well defined. 13 unrelated families, including 34 patients and 21 unaffected members were examined.

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Although this model has been serviceable, it does not adequately explain the phenotypic variability within families. Cell motility and invasiveness of vector or wild-type EBP1-transfected ACC-M cell lines were evaluated using wound healing and Boyden chamber assays. si-PLK1 encapsulated within YSK-MEND was prepared using the tertiary butanol dilution method. The addition of H(2)O(2) and HCHO in the mechanism allows the reproduction of the observed low NO(2)(-) concentration.

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Annual rates of asthma were calculated from population estimates for 2005, 2006, and 2007 and number of asthma hospital discharge and emergency department visits. Cellular mechanisms for increased fetal hemoglobin production in culture. Cultural, self-esteem, and demographic features were differentially associated with perception of personal discrimination versus perception of group discrimination. Although sequence heterogeneity was observed, six of seven human isolates contained human genotype SSU rRNA genes and one human isolate contained bovine genotype genes. Four-dimensional echocardiography with spatiotemporal image correlation and inversion mode for detection of congenital heart disease.

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This paper describes some of the difficulties and proposes appropriate remedies. The finding that presynaptic terminals persist in the absence of the muscle indicates that the muscle and its innervation follow programs of development that are at least partially independent and reinforces the concept that in insects motorneurons, and perhaps neurons in general, are not dependent upon trophic influences from their targets for survival and maintenance of their differentiated phenotype. delta-Catenin associates with adhesive junctions and facilitates cellular morphogenesis (Lu et al., 1999). The tumor growth curve for each of the animals was constructed and the mean slope of growth calculated for each group.

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Dimensions and attachments of the ankle ligaments: evaluation for ligament reconstruction. The membrane-anchored matrix metalloproteinase MT1-MMP (also known as Mmp14) plays a key role in the angiogenic process, but the mechanisms underlying its spatiotemporal regulation in the in vivo setting have not been defined.

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Two newly derived ICCs, appropriate to situations with 3 random factors (patients, examiners, and occasions) that bear a crossed (as opposed to nested) interrelationship, were applied to data from an experiment with random crossed factors. Use of autotutorial instructional methods to pretrain undergraduate pharmacy clerkship students.

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A model of slow protein release by combining VEGF(165) and bFGF with fibrin sealant was produced. The incidence and consequences of post-operative infections in patients undergoing major elective surgery is not well understood. HS6ST-2 RNAi resulted in a higher frequency of limb truncation and a more marked change in both Fgf-8 and Fgf-10 expressions than that achieved with HS6ST-1 RNAi. Arthroscopic treatment of Snyder II type of superior labrum anterior and posterior injury by absorbable anchors through anterior and posterior approach

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To determine the efficacy of Nd:YAG vitreolysis and pars plana vitrectomy in the treatment of vitreous floaters. Some features of nuclear genome transcription at early stages of liver regeneration. The YI-4, EATQ-R and ACS were administered to a sample of 1,240 adolescents between 11 and 17 years of age. The induction of caspases 3/7, 8, and 9, the breakdown of mitochondrial transmembrane potential, the BCL-2/BAX ratio, and the DNA content of cells were measured as indicators of apoptosis. Ectopic expression of DWnt-2 in the wing hinge during pupation can also create defects in muscle patterning without alterations in stripe expression.

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This study provides follow-up of primary modified Pereyra needle urethropexy procedures performed with permanent suture by residents at a military teaching hospital. The previously unreported CT findings of supracardiac anomalous pulmonary venous return and Takayasu arteritis are presented. Productivity standards: a management skill for leaders in practice.

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A fused-silica capillary gas chromatographic method is described for the determination of dye intermediates in oxidative hair dyes. The effect of some factors (age of the culture, NAA or glucose concentrations of the medium, light intensity) has been studied in two of these strains, one with a low accumulative capacity, the other with a high accumulative capacity. Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54. A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis. The flow in these regions is characterized by unsteadiness and often separation.

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Induced differentiation and signaling factor PTEN expression of 3T3-L1 adipocytes Although a clear mechanism remains still unknown, clinicians must take into consideration an association of GA in patients with T1D or AT to avoid unnecessary medical investigations and/or inadequate pharmacological treatment. In the land of the giants: a look at multi-hospital systems and group purchasing organizations. Rapid magnetic resonance imaging vs radiographs for patients with low back pain: a randomized controlled trial.

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Bronchoalveolar lavage of the two patients with active cavitary tuberculosis showed striking upregulation of the MMP-9 gene compared with a normal control using Northern analysis. A 28-year-old male was found on CT metrizamide myelography to have an intradural extramedullary tumor at the T8-T9 level. Clear association between serum levels of adipokines and T-helper 17-related cytokines in patients with psoriasis. In order to explore the sometimes subtle influence of racial determinants in decisions about resource allocation, we present the case of a 53-year-old Australian Aboriginal woman with end-stage renal failure. The risk factors for postoperative delirium include patient characteristics such as advanced age, poor preoperative functional state, depression, and abnormal serum levels of sodium, potassium, glucose and albumin.

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Sequence motifs and proteolytic cleavage of the collagen-like glycoprotein BclA required for its attachment to the exosporium of Bacillus anthracis. Compact devices for wavelength division multiplexing and demultiplexing, believed to be novel, are presented. We studied protein complexes in Saccharomyces cerevisiae, complexes of known three-dimensional structure in the Protein Data Bank and clusters of pairwise protein interactions in the networks of several organisms. Despite the abundance of evidence linking tobacco consumption to many oral conditions, no systematic review of the relationship with dental caries is available.

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In the present article, we study the effect of changes in the different parameters of the polynomial expressions for two-drug and three-drug mixtures, on the geometrical shapes of several 2-dimensional representations of the 3-dimensional concentration-effect surface. SIRT6-deficient mice developed cardiac hypertrophy and heart failure, whereas SIRT6 transgenic mice were protected from hypertrophic stimuli, indicating that SIRT6 acts as a negative regulator of cardiac hypertrophy. The results showed that both drugs attenuated the development of stressor-induced CPP. Our study objectives were to assess this accuracy and compare the percentage time within therapeutic range (PTWTR) based on HAT data to that obtained with testing through an anticoagulation clinic service (ACS).

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Comparison between replacement at 4 days and 7 days of the infection rate for pulmonary artery catheters in an intensive care unit. Prevalence and correlates of DSM-IV substance use disorders in Puerto Rico.

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Outcome Expectancies for Gambling: Empirical Modeling of a Memory Network in Federal Prison Inmates. Although ST-segment depression (STD) on the admission electrocardiogram (ECG) confers adverse prognosis in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), the implications of STD on follow-up ECG remain uncertain. In contrast to neuropsychological models postulating general cognitive impairments in OCD, the present findings suggest that it is the interaction between cognition and emotion that is impaired in OCD. Combined with the meteorological factors, analysis showed that the wind speed and wind direction also directly influenced particulate concentration. Correlation between the diameter of the main renal artery and the presence of an accessory renal artery: sonographic and angiographic evaluation.

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SecA is a multifunctional protein involved in protein localization and regulation of its own expression. Results show that the stochastic simulation methods allow for the problem size tulip tree facts australia to be scaled by a factor of almost 10 in the action space, and exponentially in the state space. Assessment of traffic-related noise in three cities in the United States.

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Islet of Langerhans transplantation is considered to be the ideal treatment for type I insulin-dependent diabetes. Prevalence of skin diseases in female prisoners in Turkey: analysis of impact of prison conditions and psychological stress. Network simulations can help identify underlying mechanisms of epileptic activity that are hard to isolate in biologic preparations. A posterior shell zelapar drug information of cricoid plate was preserved in 21 patients with intact laryngeal nerve function. Using a variational approach, we have investigated the effects of the magnetic field, the impurity position, and the nitrogen and indium concentrations on impurity binding energy in a Ga1-xInxNyAs1-y/GaAs quantum well.

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