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Advagraf (Tacrolimus)

Advagraf is an effective immunosuppressive agent for the prevention of organ transplant rejection. The neurological complications of Advagraf therapy that have been reported are usually mild, i.e. tremors, paresthesia and mild organic brain syndrome, but occasionally severe, i.e. aphasia, ataxia, severe organic brain syndrome, confusion, seizures and coma. Severe neurological complications have been observed mostly after liver and lung transplantation. They are the result of high plasma FK506 levels or of a predisposing condition.

Other names for this medication:
Tacrolimus, Advagraf, Envarsus, Prograf,

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Advagraf is used with other medications to prevent rejection of a kidney, heart, or liver transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to treat a certain type of bowel condition (fistulizing Crohn's disease) in patients who cannot take or have not been successfully treated by the usual treatment. This medication may also be used to prevent rejection of other types of transplant (such as lung).

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These findings suggest that monthly variations in serum estradiol levels may influence the severity of asthma in adult females. Progress toward controlling in vivo fibrillating sheep atria using a nonlinear-dynamics-based closed-loop feedback method.

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Moreover, Dz13 abrogated smooth muscle cell repair following scraping injury in vitro and intimal thickening in injured rat carotid arteries in vivo. Its composition varies in functionally specialized regions called domains. These data indicate that intrathecal administration of cannabinoid receptor agonists may provide postoperative analgesia while reducing spinal glial activation, and that selective cannabinoid 2 receptor agonists may do so without central side effects.

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We report a 19-year-old boy diagnosed with type 3 LQTS, frequent fatal arrhythmias induced by PVCs with the identical QRS morphology. An innovative approach to geriatric acute care delivery: the Choate-Symmes experience. New evidence for the continued slow proliferation of endothelial cells from the corneal periphery throughout life comes from the microanatomy of the peripheral cornea, and the demonstration of stem cell markers and markers of DNA synthesis in this area. Retention of iceberg lettuce quality by low temperature storage and postharvest application of 1-methylcyclopropene or gibberellic acid.

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Reserpine and tetrabenazine, but not p-chlorophenylalanine caused a partial depletion of ventral spinal cord substance P (SP) and thyrotropin-releasing hormone (TRH). New experimental approaches and methods have revealed much about the processing of afferent signals from the inner organs of the body, and have allowed more accurate descriptions of these processes, as well as a more accurate determination of their functional significance in the experience and behavior of humans. ASA also enhanced significantly the mucosal MDA content and downregulated SOD and GPx mRNA, and these effects were markedly reduced by NO-ASA. If passively correctable, the digit may be realigned by soft tissue rebalancing and extensor centralization, which may preserve a more functional arc of motion than achieved with arthroplasty. Growth and mineral metabolism after treatment with calcitriol (1,25-dihydroxyvitamin D3) and phosphate supplementation.

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Cognitive processes involved in answering survey questions are not the object of this kind of test. The most significant increases in activity were in procedures for ST-segment elevation myocardial infarction and percutaneous valve implantation. This study represents a cross sectional analysis of UTI prevalence in rural western Panama conducted over the course of a 3-day medical mission. Thus, we compared the effects of acute MK801, with and without pretreatment with haloperidol or clozapine, on seven discrete spontaneous open-field activities in adult male and female rats. Second, it is possible to explain it by quick rejoining of given breaks by cell repair systems.

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Futian and Dapeng would have the highest and the lowest hospital admissions, respectively, although these districts have the highest incidence rates among all of the districts from 2013 to 2015 based on the prediction using the GM (1,1). Although nursing personnel most often sustained sharps injuries, many HCWs from different patient care occupations are involved, and underreporting obscures the magnitude of the problem. The traditional treatment of achalasia is forceful dilation of the LES. Insect cells transfected with a baculovirus vector carrying azurocidin cDNA produced a recombinant azurocidin protein. Gabexate, a protease inhibitor, has been used to prevent pancreatic damage related to ERCP.

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New minimally invasive techniques that provide cytohistological diagnosis became available. Beyond the platelet count: immature platelet fraction and thromboelastometry correlate with bleeding in patients with immune thrombocytopenia. Eurocin, a new fungal defensin: structure, lipid binding, and its mode of action. To examine the merit of this hypothesis, we explored the possibility that in the normal heart, the branching architecture of microvasculature in walls of the left ventricle (LV) and RV mature differently. These data suggest that patients with panic disorder are characterized by having a greater decrease in the activation of a left frontal avoidance-withdrawal system in situations with a negative valence.

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The IAP-IL2/15R beta chimeric gene expressed chimeric mRNA in which IAP-coding Gag-Pol mRNA was fused to IL-2/15R beta mRNA and coded for Gag-Pol-IL-2/15R beta chimeric protein. Nineteen families with hereditary abnormalities of thyroxine-binding globulin (TBG) have been studied, comprising a total of 15 males with absent TBG, and 15 females heterozygotic for this condition, and 14 males with excess of TBG and 44 heterozygotic females. Increased creatine kinase MB in the absence of acute myocardial infarction.

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Although NMP concentration decreased linearly from 6 months of age, total nucleotide concentration decreased in an exponential manner beginning at 2 months of age. These results show that cell-mediaging response in Nigerians immunity declines, but phagocyte function is unchanged during aging. Engineering the interface of emulsion droplets with emulsifiers that inhibit chemical reactions could provide a novel technique to stabilize citral and limonene.

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Thus, the time available to read traffic signs is often limited. The objectives of this study were to characterize the post-translational modifications of collagen of weight-bearing bones subjected to hindlimb unloading for 8 weeks. Effects of magnetic field on cell dedifferentiation and callus induction derived from embryo culture in bread wheat (Triticum aestivum. Previously, we have shown that low IL-12p40 mRNA expression by cervical cancer cells is associated with a poor survival of cervical cancer patients. An investigation of self-ambivalence in obsessive-compulsive disorder.

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The authors summarize new aspects presented at the VIIIth International Congress on Cystic Fibrosis in Toronto, Canada, 1980. This is a two-stage controller acting in a supervisory fashion by means of a switch logic and allowing arbitration between a neural network (NN) and a robust proportional-derivative controller. Association of splenic villous-lymphocyte lymphoma and primary biliary cirrhosis

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These interactions, however, give a net result for incorporation of label into protein which closely approximates linearity, and hides the true complexity of the underlying processes. In contrast, the therapy with nitrates in chronic heart failure has not significantly improved prognosis especially when compared with ACE-inhibitors. Effects of short chain fatty acids on a new human colon carcinoma cell line (LIM1215). In other experiments, BALB/c T cells positively selected to Mlsa,d-negative H-2-incompatible stimulator cells retained high reactivity for Mlsa determinants.

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MgATP counteracts intracellular proton inhibition of the sodium-calcium exchanger in dialysed squid axons. The characteristics of the formation and development of psychophysiological functions in ontogeny (Cherkassy, 24-27 October 1995) Comparative In Vitro Effects and In Vivo Kinetics of Antithyroid Drugs.

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Starting from the available structural information on cyclothialidine GR122222X (2), an in silico virtual screening campaign was designed combining molecular docking calculations with three-dimensional structure-based pharmacophore information. In this chapter, we describe this approach for gaining insights into the conformational changes of the peroxisome proliferator-activated receptor alpha after binding of low-molecular weight ligands. During mitosis chromosomes use a complex network of dynamic microtubules to find the cell equator in preparation for division signals. Model mixtures were separated by either reversed-phase or ion-exchange chromatography with mass spectrometry-compatible mobile phase additives. The percent-of-predicted 6MWD was better correlated with respiratory function than actual 6MWD for subjects using home NIV due to chronic hypercapnic respiratory failure with COPD, OHS, kyphoscoliosis, and parenchymal lung disease.

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Single-photon emission computed tomography (SPECT) demonstrated extensive perilesional hyperperfusion involving parts of the right parietal, temporal, and occipital cortex. These data suggest that consensus primer PCR targeted to herpesviral DNA polymerase may prove to be useful in the detection and identification of known herpesviruses in clinical samples and the initial characterization of new herpesviral genomes. In calcium mobilization, phosphatidylinositol turnover, and chemotaxis assays, vCXCL1 acted as a highly efficacious activator of both receptors, with a rather low potency for the CXCR1 receptor but comparable with CXCL5 and CXCL7. The E2/follicle index was used for evaluating efficiency of stimulation.

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A sample of 25 patients previously involved in an unrelated study evaluating femoral neck stress fractures were contacted retrospectively 5 to 7 years after their injury. Observation of atmospheric nitrous acid with DOAS in Beijing, China. In-vivo evaluation of random donor platelet concentrates from pooled buffy coats. Apoptosis is a critical event in the deletion of B lymphocytes prior to their migration to the periphery. Also, older adults, but not younger adults, responded more rapidly to green stimuli than to red stimuli in the Task 1 training latency data.

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These results emphasize the importance of phylogeny in determining batoid pectoral fin shape, however, interactions with other constraints, most notably locomotor style, are also highlighted as significant. The operative approaches, procedures, results and complications of the delayed acetabular fractures between August 1993 and August 2001 in Jishuitan Hospital were evaluated retrospectively.

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DNase treatment of the lysate and of the R4A Ab did not effect binding, indicating that the binding of R4A to the 100-kDa protein was direct and not mediated by an antigenic bridge containing DNA. However, the nature of the factor(s) that mediate angiogenesis in PCOS is less clearly understood. Expression of oestrogen and progesterone receptors in canine sebaceous gland tumours.

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Adult lumbar scoliosis is an increasingly recognized entity that may contribute to back pain. For both disc diffusion assays, use of current break points was inadequate to detect vancomycin resistance for isolates carrying the vanB gene.

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As a result of a close T-DNA insertion, the HCF152 gene was cloned and its identity confirmed by complementation of homozygous mutant plants. Comparison of kinematic responses of the head and spine for children and adults in low-speed frontal sled tests.

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CKD impaired Akt phosphorylation in satellite cells after muscle injury. The possibility of enhancing the release externally by an ultrasonic source has also been explored.

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Heterotopic vascularized murine cardiac transplantation to study graft arteriopathy. Effects of intra-medial septum injections of L-arginine, a precursor of nitric oxide, N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase, and sulpiride, a selective antagonist of dopamine D2 receptor on morphine-induced conditioned place preference (CPP) in male Wistar rats were examined. Detection of the homology among proteins by immunochemical cross-reactivity between denatured antigens. IIA coil embolization should be performed as proximal as possible to prevent interference with pelvic collateral circulation.

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In most cases CT was sufficient in workup of infectious and osseous processes. The relationship between the common acute bronchitis syndrome and atopic disease was examined using a retrospective, case-control method.

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Phased-array surface coils can provide a high SNR to image the carotid vessel wall. All the 40 isolates of Shigella were found to be positive for the ipaH gene.

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Thirty-six knees from cadavers were used for anatomic study, and 38 navigated double-bundle ACL reconstructions were evaluated for tunnel placements. To evaluate the applicative value of multimodal navigation combined with intraoperative magnetic resonance imaging system in the treatment of complex lesions of middle skull base. Mitochondrial oxidative phosphorylation and respiratory chain: review. A multicenter, randomized, investigator-blinded study of 5- and 10-day gatifloxacin versus 10-day amoxicillin/clavulanate in patients with acute bacterial sinusitis.

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Assessment of OHRQoL will be useful not only to detect oral health needs but also to evaluate the effect of oral health care in the elderly. The use of orthogonal polynomials in mixture analysis has been extended to two-dimensional data sets. These data suggested that the equilibration between intra-and extra-vascular pool takes place slowly for bilirubin and comparatively rapidly for bile acids, though they are both mostly bound to albumin in the blood.

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Contemporary posterior cruciate-retaining total knee designs have provided pain relief and improved knee function but have failed to reproduce the kinematics and stability of the normal nonarthritic knee. SSEPs were characterised by a sequence of components with unique scalp topographies. No change in joint torque or endpoint force was required or observed in the case of the unstable interaction.

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The interaction of 2-amino-4,6-dimethyl pyrimidine (ADMP) with beta-cyclodextrin (beta-CD) has been studied by means of UV absorption, steady state and time resolved fluorescence techniques. Raman lasers based on potassium gadolinium tungstate and lead tungstate crystals pumped by a to approximately 120 ps Nd: YAG laser at 1.064 microm were developed. Correlation between sleep and levels of 3 hormones in the peripheral blood plasma in healthy persons.

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Pain assessment of postoperative older patients should be conducted during movement. Juvenile spring eruption is a relatively common dermatological condition among primary school aged children in Dunedin, especially boys. These experiments establish cAMP as a negative regulator of prodigiosin production in S.

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To probe the of Gufuhuotang effect on hemorheology and lipid metabolism of hormonal necrosis of femoral head. 2,4-Dichlorophenoxyacetic acid (2,4-D) treatment increased ADH specific activity as much as 14-fold. Elective induction of labor, or induction of labor without a medical indication, is a commonly performed procedure. Among these, two different techniques have been used: island compound transfer from a finger bank (10) and free vascularized transfer from the second toe (10) or from a non replantable finger (1). Early enteral tube feeding (initiated within 48 h of intensive care unit admission) may account for this observation.

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Mutilations of the dentition in Africa: a review with personal observations. We report a case of a 67-year-old man who underwent mitral valve replacement and Cox Maze IV procedure.

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The next 5 years: what role will women RPhs play in pharmacy practice? Multiplex PCR assay for the detection of enterotoxic Bacillus cereus group strains and its application in food matrices. Effects of fish oil on oxidation resistance of VLDL in hypertriglyceridemic patients. Controversy exists regarding the influence of sentinel lymph node (SLN) mapping technique or patient variables on the success rate of SLN mapping.

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The bulimia-specific volume enlargement of the ventral striatum is discussed in the framework of negative reinforcement through purging and associated weight regulation. We recently noted an unusual complication of PVS with a Denver shunt. Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice.

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Our findings suggest that there is not an increased risk of ovarian cancer in women who have taken some types of antidepressants or benzodiazepines. Impaired neuropsychological function alone makes a contribution to aggression. The authors show that the techniques of end plate osteotomy with concave osteophyte excision is a clinically valuable technique for the treatment of adults with fixed lumbosacral fractional curves. It involved the recruitment of 103 fourth-year tutors to facilitate the running and feedback of OSCE stations to 245 third-year medical students prior to their summative end-of-year exam. Neurobiological relationships between ambient lighting and the startle response to acoustic stress in humans.

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Since, vascular endothelial cells constitute the first line exposure to the blood-borne agents, it is plausible that anti-angiogenic activity of phytochemicals could be associated with lowering the risk of cancer by preventing the growth and metastasis of tumor. Aggregation, patterning, translation, trapping and size-based separation of microorganisms performed with the technique firmly establishes its usefulness for development of a high-performance on-chip bioassay system. Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings? Altered gene expression in an embolic stroke model after thrombolysis with tissue plasminogen activator and Stachybotrys microspora triprenyl phenol-7. The situation is considered of importance because it emphasizes the need for early recognition and possible intervention in the presence of hypoglossal symptoms.

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Benign lung lesions, lung lesions smaller than 1.5 cm (which pose technical difficulty), and lung lesions larger than 5 cm (which are associated with a higher necrosis rate) affect diagnostic accuracy of CT-guided percutaneous coaxial cutting needle biopsy of lung lesions. Complicated cases of digital amputation, such as fingertip amputations, multidigital amputations, and so forth, pose an even greater challenge, requiring extraordinary solutions for successful replantation. UCAV path planning aims to obtain an optimal flight route with the threats and constraints in the combat field well considered. The study clarifies that patient participation can be explained as an interactional process identified as mutuality in negotiation based on four components.

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Cross sectional comparisons of sociodemographic characteristics, mental health problems and health expenditures of children whose cilnidipine vs amlodipine pptx parents either do or do not report depression in the 1997 Medical Expenditure Panel Survey data. In non-treated rats dopamine induced a slight excitation or depression of the firing rate of CA 1 pyramidal neurons in slice preparations.

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We identified three Swedish FRDA patients with an FXN p.R165P missense mutation and compared their clinical features with six homozygote trinucleotide repeat expansion carriers. We used a temperature-sensitive prestance 5-10-5 fertilizer brands dlg allele to demonstrate that there are two stages, late embryogenesis and larval stages, at which dlg is necessary for normal formation of synapses. Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA. However, variegated results so far have been obtained from studies into the behaviour of high-density lipoproteins.

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The results suggest that although most rating measures do cluster around latent traits as hypothesized, there is more method variance in the data set than trait variance. We report a male with atypical severe combined immunodeficiency caused by heterozygous compound mutations c.256-257del and c.C1331T in RAG1 gene. Initiation of home mechanical ventilation in children with neuromuscular diseases. This simple, bisoprolol fumarate tablets usp monograph sorbitan non-intrusive technique can show in great detail the spatial-temporal behavior of the infectious process.

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The results support the continued investigation of metal on metal joint replacements for younger, active patients. We describe here a convenient procedure for assessing the relative cell permeability of chemical compounds. To evaluate the association between findings from drug-induced sleep endoscopy (DISE) and lateral cephalometry in obstructive sleep apnea (OSA) STUDY DESIGN: Cross-sectional. First bactox antibiotics and alcohol evidence-based guideline for breast cancer management on the internet

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Phase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults. Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases. Treatment of sagittal synostosis: subtotal cranial vault remodelling with right-angled Z-osteotomies. This kinase both participates in gonadotropin-induced resumption valacyclovir vs acyclovir for chicken pox of meiosis, as well as promoting the metaphase I to anaphase I transition. Research consistently showed that social interaction can influence EF skills in young children.

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Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem dosier 2.5 mg cells. Approaches to identifying both effective and cost-effective practices have become central to rationing decisions in the NHS. However, a combination regimen of platinum and amrubicin for elderly patients has not been reported.

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Bleomycin-inactivating activity in the acyclovir capsule 400 mg pret mutant cell extracts was three to fourfold higher than that in extracts of the parental CHO cell. Virgibacillus halodenitrificans 1806 is an endospore-forming halophilic bacterium isolated from salterns in Korea. Insect behavioural responses to changes in a volatile blend after stemborer oviposition on an African grass. alpha-Ammonium also destabilizes a benzyl radical, whereas alpha-phosphonium and alpha-sulfonium either slightly stabilize or destabilize a benzyl radical depending on their alkylation state. A novel single-step self-assembly approach for the fabrication of tissue-engineered vascular constructs.

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Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin. The patients received psoralen plus ultraviolet (PUVA), electron beam or cytostatic treatments. Experimental results show our algorithms adapin medication dictionary are highly accurate and outperform all competitive approaches. In this study, 29 ISSHL patients and 29 healthy controls were evaluated. Here we derive an explicit steady-state hepatic clearance equation that includes these factors.

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The ability of VSMC to produce PGI(2) was downregulated by mPGES-1 expression and was restored when mPGES-1 expression was silenced. Such benidipine fda approval responses can combine behavioural and physiological processes, and can be mediated through different components of the ejaculate such as sperm numbers and seminal proteins. To achieve a high degree of versatility the Miro robotic surgery platform (MRSP) consists of versatile components, dedicated front-ends towards surgery and configurable interfaces for the surgeon. Upper urinary tract tumour after radical cystectomy for transitional cell carcinoma of the bladder: an update on the risk factors, surveillance regimens and treatments. A method of analytical differentiation is developed for processing differential absorption lidar (DIAL) data.

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