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Actinum (Oxcarbazepine)
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Oxcarbazepine

Actinum is a second-generation antiepileptic drug (AED) with proven efficacy in managing partial epileptic seizures, with or without secondary generalization, in adults and children. The overlap between the underlying pathophysiologic mechanisms of some epilepsy models and neuropathic pain models supports the rationale for using certain AEDs in the treatment of neuropathic pain. Several AEDs have reportedly produced analgesia in a range of neuropathic pains, including painful diabetic neuropathy (PDN) and post-herpetic neuralgia. Increasing evidence suggests that Actinum can provide significant analgesia in several neuropathic pain conditions, including trigeminal neuralgia and PDN, and is also may be effective in treating neuropathic pain refractory to other AEDs, such as carbamazepine and gabapentin. The analgesic effects of Actinum, and its generally improved safety and tolerability profile compared with other standard AEDs, suggests that Actinum will be an important addition to the neuropathic pain armamentarium.

Other names for this medication:
Oxcarbazepine, Trileptal, Actinum, Apydan, Auram, Aurene, Deprectal, Leptal, Oxcarbazepin, Oxcarbazepina, Oxetol, Oxicodal, Tolep,

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Actinum comes as a tablet, an extended-release tablet, and a suspension (liquid) to take by mouth. The tablet and suspension are usually taken every 12 hours (twice a day) with or without food. The extended-release tablet is usually taken once a day on an empty stomach, 1 hour before or 2 hours after a meal. Take Actinum at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Actinum exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well right before each use to mix the medication evenly. Use the oral dosing syringe that came with the medication to withdraw the right amount of suspension from the bottle. You can swallow the suspension straight from the syringe or you can mix it with a small glass of water and swallow the mixture. Wash the syringe with warm water and allow it to dry thoroughly after use.

Swallow the extended-release tablets whole with water or another liquid; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of Actinum and gradually increase your dose, not more often than once every 3 days. If you were taking another medication to treat your seizures and are switching to Actinum, your doctor may gradually decrease your dose of the other medication while increasing your dose of Actinum. Follow these directions carefully and ask your doctor if you are not sure how much medication you should take.

Actinum may help control your seizures but will not cure your condition. Continue to take Actinum even if you feel well. Do not stop taking Actinum without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking Actinum, your seizures may get worse. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Actinum and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

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