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Acifar (Acyclovir)
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Acyclovir

Acifar is an antiviral drug, a synthetic nucleoside analogue, that has inhibitory activity (interferes with viral replication) against the herpes viruses, including herpes simplex 1 and 2 (cold sores and genital herpes), varicella-zoster (shingles and chickenpox), and Epstein-Barr virus (mononucleosis). Viruses take over living cells and reproduce themselves, often at the expense of the host cell. The Acifar is converted to an active form by the virus itself, and the virus then uses the active form of Acifar rather than the nucleoside it normally uses to manufacture DNA, a critical component of viral replication. Incorporation of active Acifar into new viral DNA stops the production of the DNA. Virally infected cells absorb more Acifar than normal cells and convert more of it to the active form, which prolongs its antiviral activity. The FDA approved Acifar in March 1982.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Acifar is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time). Acifar is also sometimes used to prevent outbreaks of genital herpes in people who are infected with the virus. Acifar is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body. Acifar will not cure genital herpes and may not stop the spread of genital herpes to other people.

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Critical evaluation of the protracted use of somatostatin in the conservative treatment of complex pancreatico-duodenal fistulas However, a precise role for FANCM in DNA repair remains elusive.

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Evaluation of a comprehensive care clinic model for children with brain tumor and risk for hypothalamic obesity. No differences in BMI were shown between 18-year-old twins and children from the general population, whereas the siblings of twins had increased BMI values compared with the general population. The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells. In particular, the quantitative assessment of skin in terms of hemoglobin and melanin content, as well as in terms of its light scattering properties, is a challenging problem in dermatology.

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The molecular structure and vibrational spectra of 2-chloro-N-(diethylcarbamothioyl)benzamide by Hartree-Fock and density functional methods. Prostate-specific antigen kallikrein, non-ST elevation myocardial infarction and a new-onset atrial fibrillation in hypertensive patients. Before surgery and at follow-up, patients completed the Oswestry Disability Index, SF-36, and assessment of leg pain using the Visual Analog Scale.

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Considerations for preparing a randomized population health intervention trial: lessons from a South African-Canadian partnership to improve the health of health workers. Unique differences in physiologic and perceptual responses with bronchodilation demonstrate advantages of treadmill walking as an exercise stimulus.

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The underlying physical mechanism of the nonlinear excitation energy transfer and nonlinear emissions are further investigated and discussed by using time-resolved photoluminescence and finite-difference time-domain numerical simulations. Passive marker tracking via phase-only cross correlation (POCC) for MR-guided needle interventions: initial in vivo experience. An intramedullary ependymal cyst is a rare lesion of dysembryoplastic origin.

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In contrast, IgG3(-/-) mice made similar titers of anti-PS IgM and IgG1 as WT mice but no IgG3, and had poorly opsonic sera with significantly increased mortality after S. In one non post-partum woman who induced lactation for the purpose of breast-feeding an adopted infant, OT and PRL were measured before and during mechanical pump and tactile stimulation before initiation of breast-feeding. Previous studies have demonstrated that stereocilia micromechanics change during exposure to intense stimulation, and then recover after the stimulus has ended. The origins and ramifications of the defense are reviewed with emphasis on its highly reactive nature. What you always needed to know about electroporation based DNA vaccines.

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Patients with pulmonary hypertension (PH) can decompensate to the point where they require care in the intensive care unit (ICU). Chordoma: review of clinicoradiological features and factors affecting survival. Two out of five immunodominant murine peptides were able to induce proliferation in NOD and NOD-asp Mt60 T cell lines, but not in Biozzi AB/H T cell lines. Treatments of non-small cell lung cancer (NSCLC), the most common form of lung cancer, still remain poor. Third, eight chromosomal regions where quantitative trait loci, identified by crossbreeding experiments with informative strains of mice, are defined.

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A human capital approach was used to estimate lost productivity. Gamma-aminobutyric acid (GABA) uptake and acetylcholinesterase (AChE) content were demonstrated concurrently in cortical neurons grown in tissue culture. The spectroscopic constants have been calculated for 56 electronic states.

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Depletion of SGT1 with siRNA did not affect stability of Nod1 protein or of downstream signaling molecules but did prevent multiple cellular responses associated with Nod1 activation. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated by dense vesicles is now challenged as novel routes are being disclosed and vacuoles with intermediate characteristics described. We characterize the prevalence of hypospadias in Arkansas with consideration of the degree of hypospadias.

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Antileishmanial activity of a linalool-rich essential oil from Croton cajucara. Reduction of exposure and cessation of smoking seem to be the major preventive measures to avoid respiratory disorders in the aluminum industry. The authors discuss the advantages and disadvantages of Intranet-based instructional modules, instruction on developing Intranet-based modules, and an example of a healthcare system that is effectively using intranet-based modules for competency training.

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The liver is the natural microenvironment for hepatocytes transplantation but unfortunately engraftment efficiency is low. The exact mechanisms through which TREM-1 influences TLR and NLR pathways are still largely elusive. This shows that hindbrain plasticity is evolutionarily conserved and implies rhombomeres may be undergoing continual assessment of their identities. Pulmonary surfactant dysfunction in congenital diaphragmatic hernia: experimental and clinical findings.

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Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. The Dichlorofluorescein diacetate (DCFH-DA) cytofluorimetric test confirmed the strong scavenging action exerted by Ellagic Acid. This study established proof-of-concept that the attenuated replicating MVTT(ZCI) may serve as a safe noninvasive smallpox vaccine candidate. A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats: role of lovastatin therapy.

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In spite of this, very little is known about the chemical composition of its polar extracts. In the present study, we evaluated the association of SNP in the MCP-1 gene with diabetic retinopathy (DR) and diabetic macular edema (DME) in a Chinese population from Northern China with type 2 diabetes.

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Primary gastrointestinal lymphoma incidence, clinical presentation, and surgical approach. All three contained receptors for Dex, but only two responded by undergoing apoptosis.

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Intraoperative assessment of coronary artery bypass grafts (CABG) anastomotic quality can be performed using transit-time flowmetry (TTF). The increase in LV dyssynchrony during exercise strongly correlates with the increase in mitral regurgitation severity and with the impairment of LV stroke volume. This review provides rationale and summarizes recent evidence supporting this novel approach to skeletal anabolism. We should consider the possibility of splenic tumors arising from the spleen and intrapancreatic accessory spleen when we find similar lesions in the spleen and the tail of the pancreas. This study assessed the long-term effectiveness of push enteroscopic cauterization of bleeding intestinal angiodysplasia.

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The glide paths provide long-term guidance for LDV powertrain/fuel development. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species. It appears stringent donor selection procedures reduced HCV infection in multi-transfused patients, but it is still serious risk for these subjects. Polycyclic-type pigments containing dioxazine violet (pigment violet (PV) 23, PV37) and diketopyrrolopyrrole (PR254, PR255) were found to contain PCB-56, PCB-77, PCB-40, PCB-5, and PCB-12, and PCB-6, PCB-13, and PCB-15, respectively, as major congeners.

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Partial Cricotracheal Resection (PCTR), a Rewarding Outcome for Paediatric Subglottic Stenosis: An Early Experience. Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors.

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Stepping across the line: information sharing, truth telling, and the role of the personal carer in the Australian nursing home. The starting doses were IRN 80 mg/m(2) given over 90 min on days 1, 8, 22, 29, and capecitabine 1,500 mg/m(2)/day given days 2-15 and 23-36. To clarify the effect of urinary pH on chemical shift of citrate, we compared 1H-NMR spectra of urine samples obtained from selenium-treated mice and untreated mice as well as those from untreated rats. Generation of a life-expanded rhesus monkey fibroblast cell line for the growth of rhesus rhadinovirus (RRV). Intracellular recording reveals that trigger motor neurons can generate regular as well as particularly large postsynaptic potentials, which might be passively propagated over the short distance to the trigger muscle.

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To effectively understand and solve complex problems resulting from this agricultural revolution, expanded communications are needed at a variety of levels. Features of epidermal growth factor receptor (EGFR) expression in osteosarcoma and loxone vs logo for shoes in vitro efficacies of EGFR inhibitors against osteosarcoma cells were evaluated. Measuring by Epworth scale of sleepiness we found out that the patients with epilepsy suffered from a significantly higher daytime sleepiness than the healthy controls. Eversion vs conventional carotid endarterectomy: a systematic review. Furthermore, variation in testosterone concentrations were not due to males gathering together in large parties, as their levels in these situations did not exceed baseline.

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